Essentials of Genetics, Global Edition eBook, 10th Edition

William S. Klug all

Essentials of Genetics, Global Edition eBook, 10th Edition

By William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
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For all introductory genetics courses.

Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today’s students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topics chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasise ethical considerations that genetics is bringing into everyday life.

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  • Expanded coverage of regulation of gene expression. Previously covered in a single chapter, regulation of gene expression is now divided into coverage of bacteria in Chapter 15 and coverage of eukaryotes in Chapter 16. Chapter 15 concludes with an introduction to CRISPR-Cas, and Chapter 16 includes thoughtful coverage of geneticists’ important work in posttranscriptional regulation the past 15 years, including coverage of alternative splicing, mRNA stability and decay, and regulatory noncoding RNAs.
  • Special Topic chapter on Genetic Testing guides students through the many contexts in which genetic testing is becoming prominent and explores many questions and ethical concerns related to its use.
  • Special Topic chapter on Advances in Neurogenetics: The Study of Huntington Disease, explores how genetic analysis has informed scientists about the disease’s causes, symptoms, and future treatment. All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions. Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Mastering Genetics.
  • Coverage of CRISPR-Cas is now integrated in multiple chapters. The impact of genome editing is briefly introduced in Chapter 1. A basic overview of how the mechanism works in bacteria is covered in Chapter 15. Applications to biotechnology are explored in Chapter 17. Additionally, the use of CRISPR-Cas for genome editing for gene therapy and the production of genetically modified foods is covered in Special Topic Chapters ST3 and ST6.
  • An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues. Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society. In addition, all chapters end with a Case Study, each of which raises ethical questions.
  • Genetics, Ethics, and Society essays provide a synopsis of an ethical issue related to a current finding in genetics that impacts directly on society today. It includes a section called Your Turn, which directs students to related resources of short readings and websites to support deeper investigation and discussion of the main topic of each essay.
  • Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues, and they include ethical considerations.
  • Exploring Genomics boxes help students apply genetics to modern techniques such as genomics, bioinformatics, and proteomics. These boxes illustrate how genomic studies have an impact on every aspect of genetics. Exercises provide thoughtful questions and direct students to related online resources, allowing them to increase their awareness of genomics.
  • Now Solve This Problems are integrated throughout each chapter to test student knowledge and build problem-solving skills while learning chapter content. Exercises include a hint to guide students and a brief answer is provided in the answers appendix. One Now Solve This problem per chapter is linked to related end-of-chapter problems to make it easier for professors to assign similar problems for homework.
  • How Do We Know? questions appear as the first entry in the Problems and Discussion Questions and ask students to identify the experimental basis underlying important concepts and conclusions–that is, how we know what we know. Students are asked to review numerous findings discussed in the chapter and to summarise the process of discovery that was involved.
  • Insights and Solutions sections strengthen students’ problem-solving skills by showing step-by-step solutions and rationales for select problems.
  • Essential Points, integrated throughout each chapter, draw student attention to key issues and concepts that have been discussed in the text, helping them identify important information.
  • A Concept Question, found as the second question in the Problems and Discussion Questions, asks the student to review and comment on common aspects of the Key Concepts listed at the beginning of each chapter. This feature places added emphasis on the pedagogic approach of conceptual learning.
  • Evolving Concept of the Gene is a short feature, integrated in appropriate chapters, that highlights how scientists’ understanding of what a gene is has changed over time. Since we cannot see genes, we must infer just what this unit of heredity is, based on experimental findings. By highlighting how scientists’ conceptualisation of the gene has advanced over time, this feature helps students appreciate the process of discovery that has lead to an even more sophisticated understanding of hereditary information.
Table of contents
  • 1. Introduction to Genetics
  • 2. Mitosis and Meiosis
  • 3. Mendelian Genetics
  • 4. Modification of Mendelian Ratios
  • 5. Sex Determination and Sex Chromosomes
  • 6. Chromosome Mutations: Variation in Number and Arrangement
  • 7. Linkage and Chromosome Mapping in Eukaryotes
  • 8. Genetic Analysis and Mapping in Bacteria and Bacteriophages
  • 9. DNA Structure and Analysis
  • 10. DNA Replication
  • 11. Chromosome Structure and DNA Sequence Organization
  • 12. The Genetic Code and Transcription
  • 13. Translation and Proteins
  • 14. Gene Mutation, DNA Repair, and Transposition
  • 15. Regulation of Gene Expression in Bacteria
  • 16. Regulation of Gene Expression in Eukaryotes
  • 17. Recombinant DNA Technology
  • 18. Genomics, Bioinformatics, and Proteomics
  • 19. The Genetics of Cancer
  • 20. Quantitative Genetics and Multifactorial Traits
  • 21. Population and Evolutionary Genetics