Concepts of Genetics, Global Edition, 12th Edition

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Concepts of Genetics, Global Edition, 12th Edition

By William Klug, Michael Cummings, Charlotte Spencer, Michael Palladino, Darrell Killian
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For all introductory genetics courses.

Concepts of Genetics emphasises the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. This best-selling text continues to provide understandable explanations of complex, analytical topics and recognises the importance of teaching students how to become effective problem solvers.

The 12th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas and the study of posttranscriptional gene regulation in eukaryotes. An expanded emphasis on ethical considerations that genetics is bringing into everyday life is addressed in Genetics, Ethics, and Society and Case Study features.
  • Two new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including CRISPR-Cas and Genomic Editing and Advances in Neurogenetics: The Study of Huntington Disease.
  • All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions.
  • Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Mastering Genetics.
  • Reorganised and expanded coverage of gene regulation in eukaryotes reflects recent discoveries that reveal how RNA in many forms plays critical roles in the regulation of eukaryotic gene activity. A single chapter on this topic in previous editions has been expanded to three:
  • Transcriptional Regulation in Eukaryotes (Chapter 17), Posttranscriptional Regulation in Eukaryotes (Chapter 18), and Epigenetics (Chapter 19).
  • An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues. Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society. In addition, each chapter ends with a Case Study, each of which raises ethical questions.
  • Modern Approaches to Understanding Gene Function feature challenges students to understand how modern gene targeting approaches (such as the use of transgenic animals, knockout animals, and RNA interference) have dramatically advanced our understanding of gene function. Each entry highlights representative experimental approaches, analyses experimental data, and relates to a concept discussed in the chapter. Each feature includes questions for further analysis or discussion.
Table of contents
  • Part One--Genes, Chromosomes, and Heredity
  • 1 Introduction to Genetics
  • 2 Mitosis and Meiosis
  • 3 Mendelian Genetics
  • 4 Extensions of Mendelian Genetics
  • 5 Sex Determination and Sex Chromosomes
  • 6 Chromosomal Mutations: Variation in Number and Arrangement
  • 7 Chromosome Mapping in Eukaryotes
  • 8 Genetic Analysis and Mapping in Bacteria and Bacteriophages
  • 9 Extranuclear Inheritance
  • Part Two--DNA: Structure, Replication, and Organization
  • 10 DNA Structure and Analysis
  • 11 DNA Replication and Recombination
  • 12 DNA Organization in Chromosomes
  • Part Three--Gene Expression and Its Regulation
  • 13 The Genetic Code and Transcription
  • 14 Translation and Proteins
  • 15 Gene Mutation, DNA Repair, and Transposition
  • 16 Regulation of Gene Expression in Bacteria
  • 17 Transcriptional Regulation in Eukaryotes
  • 18 Posttranscriptional Regulation in Eukaryotes
  • 19 Epigenetic Regulation of Gene Expression
  • Part Four--Genomics
  • 20 Recombinant DNA Technology
  • 21 Genomic Analysis
  • 22 Applications of Genetic Engineering and Biotechnology
  • Part Five--Genetics of Organisms and Populations
  • 23 Developmental Genetics
  • 24 Cancer Genetics
  • 25 Quantitative Genetics and Multifactorial Traits
  • 26 Population and Evolutionary Genetics
  • Special Topics in Modern Genetics
  • ST1 CRISPR and Genome Editing
  • ST2 DNA Forensics
  • ST3 Genomics and Precision Medicine
  • ST4 Genetically Modified Foods
  • ST5 Gene Therapy
  • ST6 Advances in Neurogenetics: The Study of Huntington Disease
  • Appendix A Selected Readings
  • Appendix B Answers to Selected Problems