Biochemistry with Premium Website (4e)

The fourth edition of Biochemistry  preserves the clear writing, strong physical chemistry background, and the use of the "Tools of Biochemistry" feature to underscore the experimental nature of biochemistry.  This edition has been comprehensively and consistently updated to present the current developments in a rapidly evolving field.

Part I          The Realm of Biochemistry

Chapter 1    The Scope of Biochemistry

Chapter 2    The Matrix of Life: Weak Interactions in an Aqueous Environment

Chapter 3    The Energetics of Life

 

Part II         Molecular Architecture of Living Matter

Chapter 4    Nucleic Acids

Chapter 5    Introduction to Proteins: The Primary Level of Protein Structure

Chapter 6    The Three-Dimensional Structure of Proteins

Chapter 7    Protein Function and Evolution

Chapter 8    Proteins in Motion: Contractile Systems and Molecular Motors

Chapter 9    Carbohydrates: Sugars, Saccharides, Glycans

Chapter 10   Lipids, Membranes, and Cellular Transportation

 

Part III        Dynamics of Life: Catalysis and Control of Biochemical Reactions

Chapter 11   Enzymes: Biological Catalysts

Chapter 12   Chemical Logic of Metabolism

 

Part IV        Dynamics of Life: Energy, Biosynthesis, and Utilization of Precursors

Chapter 13   Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway

Chapter 14   Citric Acid Cycle and Glyoxylate Cycle

Chapter 15   Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism

Chapter 16   Photosynthesis

Chapter 17   Lipid Metabolism I: Fatty Acids, Triacylglycerols, and Lipoproteins

Chapter 18   Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates

Chapter 19   Lipid Metabolism II: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids

Chapter 20   Metabolism of Nitrogenous Compounds: Principles of Biosynthesis, Utilization, and Turnover

Chapter 21   Metabolism of Nitrogenous Compounds: Amino Acids, Porphyrins, and Neurotransmitters

Chapter 22   Nucleotide Metabolism

Chapter 23   Mechanisms of Signal Transduction

 

Part V         Information

Chapter 24   Genes, Genomes, and Chromosome

Chapter 25   DNA Replication

Chapter 26   DNA Restructuring: Repair, Recombination, Rearrangement, Amplification

Chapter 27   Information Readout: Transcription and Post-transcriptional Processing

Chapter 28   Information Decoding: Translation and Post-translational Protein Processing

Chapter 29   Regulation of Gene Expression

 

Answers to Problems

Glossary

Index

• NEW - Co-authors.  Organization and comprehensiveness of previous editions have been strengthened by the complementary strengths of three principle authors:
  • Spencer J. Anthony-Cahill in structural and mechanistic biochemistry
  • Dean R. Appling in metabolic biochemistry and mechanistic enzymology
  • Christopher K. Mathews in genetic biochemistry and metabolic enzymology
    
• NEW - Updated "Tools of Biochemistry" sections.  These popular sections have been updated and expanded to include new topics, such as Introduction to Proteomics, Tandem Mass Spectrometry, Nuclear Magnetic Resonance Spectroscopy, In Vitro Evolution of Protein Function, Metabolomics, Targeted Gene Disruption, and more.
  
• NEW - Keeping current with today's discoveries.  Expanded presentation of mechanisms of enzyme-catalyzed reactions, while maintaining the indissoluble link between the biological and chemical sides of biochemistry.  Significant reorganization in the chapters dealing with intermediary metabolism and with genetic biochemistry.  Partial list of new or significantly revised topics include:
  • Phosphorothioate bonds in DNA; the evolution of metabolic pathways; energy homeostasis, calorie restriction and lifespan extension; DNA methylation and epigenetics; chromatin remodelling and transcriptional control; RNA interference, noncoding RNAs, and riboswitches.
    
• NEW - More life science applications.  The addition of more examples of practical application of biochemical knowledge integrated into the text, including:
  • Influenza virus neuraminidase and the action of Tamiflu (Chapter 9)
  • Biofuels (Chapter 13)
  • Mitochondrial diseases (Chapter 15)
  • Artificial photosynthesis (Chapter 16)
  • Diabetes and obesity (Chapter 18)
  • Calorie restriction and lifespan extension (Chapter 18)
  • Methylenetetrahydrofolate reductase variants and disease susceptibility (Chapter 21)
  • Chromosomal translocations and targeted cancer drugs (Chapter 23)
  • Mapping disease genes (Chapter 24)
    
• NEW - Companion website with Pearson eText and animations.
  
• NEW - Engaging Questions for Students.  Wherever possible, we have removed problems that emphasize rote learning and retained or added problems that require analytical or quantitative thought to be solved.  Several new problems have been added to each chapter.
  
• NEW - Remarkable artwork.  Updating the text with over 100 new figures and pieces of art.

• Updated "Tools of Biochemistry" sections
• Keeps current with today's discoveries.  Partial list of new or significantly revised topics includes:
• phosphorothioate bonds in DNA; the evolution of metabolic pathways; energy homeostasis; calorie restriction and lifespan extension; DNA methylation and epigenetics; chromatin remodelling and transcriptional control; RNA interference, noncoding RNAs, and riboswitches
• More life science applications throughout the text including biofuels, artificial phtosynthesis, and mapping disease genes
• Companion website with Pearson eText and animations
• Engaging questions for students that require analytical or quantitative thought
• Over 100 new figures and pieces of art throughout the text