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The eighth edition of Fundamentals of Pharmacology presents key scientific and clinical principles to facilitate a greater understanding of pharmacology.
This wholly-Australasian text provides comprehensive and current coverage of topics, written in a clear style with a reader-friendly, full-colour design. The authors have implemented student focussed changes to ensure the text is easy to navigate and the content flows to aid comprehension and retention of content.
SECTION I PHARMACOLOGY WITHIN THE SOCIAL AND PROFESSIONAL CONTEXT
1 Sociocultural aspects
2 Health professionals and the law
4 The roles and responsibilities of health professionals in medicine adherence, education and advocacy
5 The roles and responsibilities of health professionals in medicine management
SECTION II MEDICINE ADMINISTRATION AND PROFESSIONAL RESPONSIBILITIES
6 Medicine formulations, storage and routes of administration
7 The clinical decision-making process
8 Medicine administration strategies and documentation
9 Medication errors
10 Management of common adverse drug reactions
11 Risk communication: balancing the benefits and risks of drug treatment
SECTION III GENERAL ASPECTS OF PHARMACOLOGY
12 Drug nomenclature
13 Pharmacokinetics: absorption and distribution
14 Pharmacokinetics: metabolism and excretion
15 Drug interactions
17 Drug development, evaluation and safety
18 Genetic considerations in pharmacology
19 Pharmacokinetic factors that modify drug action
20 Paediatric and geriatric pharmacology
SECTION IV TOXICOLOGY
21 Poisoning and envenomation
22 The management of acute clinical overdose
23 Contemporary drugs of abuse
24 Drug abuse in sport
SECTION V AUTONOMIC PHARMACOLOGY
25 General aspects of neuropharmacology
26 Adrenergic pharmacology
27 Cholinergic pharmacology
SECTION VI CHEMICAL MEDIATORS 28 An introduction to chemical mediators
29 Histamine and antihistamines
30 Prostaglandins and serotonin
31 Nitric oxide and the endothelins
SECTION VII THE MODULATION OF BEHAVIOUR, COGNITION AND MOTOR ACTIVITY
32 General concepts of psychopharmacology
33 Antipsychotic agents
34 Anxiolytics and hypnotics
35 Antidepressants and mood stabilisers
36 Medicines used in neurodegenerative disorders
37 Antiseizure agents and muscle relaxants
38 Central nervous system stimulants
SECTION VIII MEDICINES USED TO RELIEVE PAIN AND PRODUCE ANAESTHESIA
39 Opioid analgesics
40 Anti-inflammatory, antipyretic and non-opioid analgesic agents
41 Medicines used to treat migraine
42 General anaesthesia
43 Local anaesthesia
SECTION IX THE MODULATION OF OXYGENATION AND PERFUSION
44 Medicines used to lower blood lipids
45 Antihypertensive agents
46 Medicines used to promote tissue perfusion
47 Antithrombotic, fibrinolytic and haemostatic agents
48 Diuretics and other renal medicines
49 Medicines used to treat heart failure
50 Medicines used to treat cardiac dysrhythmia
51 Fluid and potassium imbalances
52 Antianaemic agents
53 Medicines used to maintain gas exchange
54 Medicines for upper respiratory tract conditions
SECTION X THE MODULATION OF GASTROINTESTINAL FUNCTION
55 Upper gastrointestinal tract drugs
56 Lower gastrointestinal tract drugs
57 Antiemetic agents
58 Enteral and parenteral nutrition
SECTION XI THE MODULATION OF BODY GROWTH, DEVELOPMENT AND METABOLISM
59 Medicines and the pituitary gland
60 Medicines and the thyroid
61 Medicines and the pancreas
62 Medicines and the adrenal cortex
63 Medicines and the gonads
64 Medicines and bone metabolism
65 Hyperuricaemia and gout
66 Obesity and its treatment
SECTION XII THE MODULATION OF CELLULAR GROWTH AND PROLIFERATION
67 Introduction to chemotherapy
68 Sulfonamides and trimethoprim
69 Antibacterial agents
70 Antituberculotics and antileprotic agents
71 Antiseptics and disinfectants
72 Antiparasitic agents
73 Antiviral agents
74 Antifungal agents
75 Immunomodulating agents
76 Cytotoxic chemotherapeutic agents
SECTION XIII MEDICINES USED TOPICALLY AND HERBAL PRODUCTS
77 Medicines used in diseases of the skin
78 Medicines and the eye
79 Herbal medicines
The organisation of the book content has been revised. The Table of Contents has been reduced from 83 chapters in 15 sections in the last edition to 79 chapters in 13 sections in this edition. This change achieves the streamlining of content and focus and should make the text less daunting for students to navigate. We have also removed brand names from the medicine summary tables at the end of most chapters to reinforce the emphasis on medication groupings and generic names.
FULL-COLOUR FIGURES AND TABLES
Chapter figures are printed in full colour, providing the representations of structures and processes with great depth and vibrancy. Receptors are rendered as G-protein-coupled or ion channels rather than basic geometric shapes. A number of new figures and tables have been included to assist students in visualising difficult pharmacological concepts, the sites of actions of drugs and the range of drug effects expected in a person when particular drug groups are administered. Concept maps linking the pharmacology and pathophysiology are included in this edition and cover the following common conditions: diabetes mellitus, rheumatoid arthritis, asthma, inflammatory bowel disease and ischaemic heart disease.
END-OF-CHAPTER AND END-OF-SECTION FEATURES
The book contains over 800 end-of-chapter questions to assist in the consolidation of learning—all of these have been reviewed. New and revised integrated case studies appear at the end of sections to assist with making links between theory and practice.
This edition reflects the availability of medicines in Australia and New Zealand at the time of publication. Consistent with information currently available to us, we have updated new medicines that have entered the marketplace, as well as those that have been removed since the last edition.
Where appropriate, the therapeutic approaches associated with the management of important clinical conditions, such as cardiovascular disease, diabetes mellitus and psychiatric illness have been brought up to date with current clinical guidelines.
Associate Professor Shane Bullock, Monash University, has been involved in the education of student health professionals and scientists for more than 25 years. Shane is the co-author of three Australian textbooks: Fundamentals of Pharmacology, Principles of Pathophysiology and Psychopharmacology for Health Professionals. He has also published a number of journal articles on health professional education, in particular with respect to pharmacology knowledge. He is currently the Director of the Monash School of Rural Health at Churchill, coordinating the first year of the graduate entry medical course.
Professor Elizabeth Manias is a Research Professor within the School of Nursing and Midwifery at Deakin University. Elizabeth is also an Adjunct Professorial Fellow at the Department of Medicine, Royal Melbourne Hospital, The University of Melbourne and an Honorary Professor at the Melbourne School of Health Sciences, The University of Melbourne. She is a registered nurse, a registered pharmacist, a certified geriatric pharmacist and is accredited to undertake Medication Management Reviews. Elizabeth has extensive experience in teaching pharmacology and medication safety to undergraduate and postgraduate students. Her research interests include medication safety, medication adherence, communication processes between health professionals, patients and family members, organisational and environmental aspects associated with patient safety, and consumer participation in care.
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